Endocrine Abstracts

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Myelinolysis is a recognised complication following over-rapid correction of hyponatraemia. However, the risk of myelinolysis following the treatment of Addisonian crisis is rarely reported. We report 2 cases of primary adrenal insufficiency (PAI) both associated with severe hyponatraemia. In the first case, myelinolysis developed following treatment with corticosteroids and isotonic saline in line with current recommendations. In the second case, deliberately cautious correct...

Background: Women with polycystic ovary syndrome (PCOS) are commonly associated with insulin resistance, metabolic syndrome and a family history of diabetes mellitus (DM). They are therefore at risk of diabetes and dyslipidaemia. Diabetes UK (2006) recommends screening for diabetes in PCOS patients who have a body mass index (BMI) ≥30. The recommended test is fasting plasma glucose (FPG). We therefore investigated 55 PCOS patients and 33 healthy volunteers to test the hy...

Backround: Recent research has heightened the controversy surrounding the effects of conventional hormone replacement therapy on cardiovascular risk, suggesting that use of HRT is associated with an increase in cardiovascular morbidity and mortality. Testosterone has also been associated with unfavourable cardiovascular parameters and the addition of testosterone to HRT may augment the risk of cardiovascular events in postmenopausal women.Aim: To elucida...

Background: Although androgens are traditionally considered to be pro-atherogenic, there is increasing evidence to suggest an inverse relationship between testosterone and cardiovascular risk. Endothelial dysfunction is an early event in the process of atherogenesis and may occur as a result of vascular oxidative damage. In vivo, human monocytes release reactive oxygen intermediates as part of a normal immune response.Aim: This study assessed the contribution of testostero...

Backgrounds and aims: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. The somatostatin (SST)-producing D-cell is an EEC of particular interest due to the profound inhibition exerted by SST over other EECs, highlighting D-cells as critical regulator of the enteroendocrine axis. The aim of this study was to profile the transcriptom...